nucleotide excision repair

Objective To investigate the association of polymorphisms of nucleotide excision repair genes and chromosomal damage in peripheral blood lymphocytes among coke-oven workers.

目的研究核苷酸剪切修复酶基因多态性与焦炉作业工人外周血淋巴细胞染色体损伤易感性的关系。

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BACKGROUND& OBJECTIVE: Xeroderma pigmentosum group C ( XPC) gene is involved in nucleotide excision repair ( NER).

背景与目的：XPC基因参与核苷酸切除修复，该基因存在单核苷酸多态性（SNP）位点，并可能通过SNP位点碱基的改变影响其修复能力及疾病易感性。

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Polymorphisms in nucleotide excision repair genes XPC and XPD and clinical responses to platinum-based chemotherapy in advanced non-small cell lung cancer

XPC和XPD基因遗传多态与晚期非小细胞肺癌对铂类药的敏感性

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At the first five days of the recovery period, the increased DNA damage may be due to the repair of DNA damage, such as base or nucleotide excision repair.

在恢复阶段的早期5天内，DNA损伤持续的增加，这应该是由于对DNA损伤的修复造成的，例如，碱基切除修复或者核苷酸切除修复。

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Nucleotide excision repair ( NER) can recognize a broad spectrum of helix-distorting lesions and is a major repair system of DNA damage.

在DNA损伤的众多修复途径中，核苷酸切除修复（NER）途径能广谱识别大多数严重损伤造成的DNA螺旋扭曲，是DNA损伤的主要修复系统，也是机体抵抗致癌效应的主要防御机制。

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The primary function of which is the base excision repair ( Base excision repair, BER) process, playing an important part in filling the single nucleotide gap.

其主要功能是碱基切除修复（base excision repair，BER），在单核苷酸缺口的填补中起重要作用。

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Effect of benzopyrene on DNA damage and expression of genes involved in nucleotide excision repair in lung cancer cells

苯并（a）芘对肺癌细胞DNA损伤及修复基因表达水平的影响

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There are many DNA repair pathways to different DNA lesions, including base excision repair, nucleotide excision repair, mismatch repair and homologous recombination repair.

针对不同的DNA损伤。细胞内有许多不同的修复方式对其进行修复，包括碱基切除修复、核苷酸切除修复、错配修复、同源重组修复等。

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Nucleotide excision repair ( NER) mechanism is essential for the maintenance of organism genome integrity.

核苷酸剪切修复（NER）途径是维持生物体基因组稳定的重要机制。

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